Welcome to Lee Makowski Lab Website
Image and signal processing as applied to biophysical data designed to answer fundamental questions about the molecular basis of living systems, with particular emphasis on the progression of Alzheimer’s Disease.
Biophysical studies of neurodegenerative disease progression
Empowering local innovation for rural healthcare.
Ghana Bioinnovation Initiative
This session was part of the 2022 Ghana Bioinnovation Workshop, where local engineers, students, and healthcare professionals received hands-on training in biomedical innovation. Facilitated by international and local experts, the workshop focused on developing practical solutions for rural healthcare challenges in Ghana.
Highlight one of your favorite projects
Our lab is at the forefront of research into Alzheimer’s disease, a complex neurodegenerative disorder that affects millions worldwide. We focus on understanding the structural and molecular changes that occur in the brain during the progression of the disease. By combining advanced imaging techniques such as X-ray microdiffraction, scanning X-ray microscopy, and computational modeling, we aim to visualize and characterize amyloid-β and tau protein aggregates—key pathological features of Alzheimer’s. Our interdisciplinary approach integrates bioengineering, physics, and data science to uncover early biomarkers, map the progression of lesions, and explore potential therapeutic strategies. This research not only deepens our understanding of Alzheimer’s but also informs broader questions about brain health and neurodegeneration.
Contact
If you are interested in learning more about our research, exploring potential collaborations, or discussing project ideas, we would be happy to hear from you. Please reach out to us via email.
Email: l.makowski@northeastern.edu